An Injection For Hunger

In which writer Paul Ford tries a new drug for Type 2 diabetes management and discovers it completely switches off his previously hyperactive hunger signal and basically goes crazy-wall for a while:

“Something’s happened,” I told my wife. She is a veteran of watching me try to fix my body. I told her: Where before my brain had been screaming, screaming, at air-raid volume—there was sudden silence. It was confusing. Would it last?

I went alone that night to a Chinese restaurant, the old-school kind with tables, and ordered General Tso’s. I ate the broccoli, a few pieces of chicken, and thought: too gloopy. I left it unfinished, went home in confusion, a different kind of sleepwalker. I passed bodegas and shrugged. At an office I observed the stack of candies and treats with no particular interest.

Decades of struggle—poof. Apparently the Mounjaro molecule targets the same hormone as Ozempic, plus a second one, so it doesn’t just stimulate insulin production but also boosts energy output.

“I urgently need,” I thought, “an analog synthesizer.” Something to fill the silence where food used to be. Every night for weeks I spent four, five hours twisting Moog knobs. Not making music. Just droning, looping, and beep-booping. I needed something to obsess over, to watch YouTube videos about. I needed something to fail at every night to feel normal. And I was also manic, dysregulated, and wide-eyed, sleeping five hours a night, run-walking, with pressured speech; my friends, happy for me but confused, called me “cocaine Paul.” I bought more synthesizers off a guy from Craigslist, meeting him in Bushwick, Brooklyn, with a grand in cash. A body is not designed to lose 25 pounds in eight weeks, starting during the holidays. Beep. Boop.